Enabling USB consumes a lot of power. So it's better to keep it disabled
by default when the serial port is set to something other than "usb"
(USB-CDC).
On my nice!nano clone, it reduces current consumption from 1mA to
0.13mA (and most of the rest is probably consumed by a connected SCD41
sensor).
This change might break some expectations, when a board uses USB but not
USB-CDC (I think this is rare, but I didn't check specifically).