diff --git a/src/machine/machine_esp32c3.go b/src/machine/machine_esp32c3.go
index 727fcc1e6..eb2a18b5e 100644
--- a/src/machine/machine_esp32c3.go
+++ b/src/machine/machine_esp32c3.go
@@ -519,6 +519,10 @@ type Serialer interface {
 	RTS() bool
 }
 
+func initUSB() {
+	// nothing to do here
+}
+
 // USB Serial/JTAG Controller
 // See esp32-c3_technical_reference_manual_en.pdf
 // pg. 736
diff --git a/src/machine/serial-usb.go b/src/machine/serial-usb.go
index 658708291..44dc63e0c 100644
--- a/src/machine/serial-usb.go
+++ b/src/machine/serial-usb.go
@@ -6,5 +6,6 @@ package machine
 var Serial Serialer
 
 func InitSerial() {
+	initUSB()
 	Serial = USBCDC
 }
diff --git a/src/machine/usb.go b/src/machine/usb.go
index 434ee0f1b..968252103 100644
--- a/src/machine/usb.go
+++ b/src/machine/usb.go
@@ -19,6 +19,17 @@ var (
 	USBCDC Serialer
 )
 
+func initUSB() {
+	enableUSBCDC()
+	USBDev.Configure(UARTConfig{})
+}
+
+// Using go:linkname here because there's a circular dependency between the
+// machine package and the machine/usb/cdc package.
+//
+//go:linkname enableUSBCDC machine/usb/cdc.EnableUSBCDC
+func enableUSBCDC()
+
 type Serialer interface {
 	WriteByte(c byte) error
 	Write(data []byte) (n int, err error)
diff --git a/src/runtime/runtime_atsamd21.go b/src/runtime/runtime_atsamd21.go
index 52bedf739..43e537708 100644
--- a/src/runtime/runtime_atsamd21.go
+++ b/src/runtime/runtime_atsamd21.go
@@ -6,7 +6,7 @@ import (
 	"device/arm"
 	"device/sam"
 	"machine"
-	"machine/usb/cdc"
+	_ "machine/usb/cdc"
 	"runtime/interrupt"
 	"runtime/volatile"
 	"unsafe"
@@ -26,8 +26,6 @@ func init() {
 	initUSBClock()
 	initADCClock()
 
-	cdc.EnableUSBCDC()
-	machine.USBDev.Configure(machine.UARTConfig{})
 	machine.InitSerial()
 }
 
diff --git a/src/runtime/runtime_atsamd51.go b/src/runtime/runtime_atsamd51.go
index f8d46275b..06fea8e11 100644
--- a/src/runtime/runtime_atsamd51.go
+++ b/src/runtime/runtime_atsamd51.go
@@ -6,7 +6,7 @@ import (
 	"device/arm"
 	"device/sam"
 	"machine"
-	"machine/usb/cdc"
+	_ "machine/usb/cdc"
 	"runtime/interrupt"
 	"runtime/volatile"
 )
@@ -27,8 +27,6 @@ func init() {
 	initADCClock()
 	enableCache()
 
-	cdc.EnableUSBCDC()
-	machine.USBDev.Configure(machine.UARTConfig{})
 	machine.InitSerial()
 }
 
diff --git a/src/runtime/runtime_nrf52840.go b/src/runtime/runtime_nrf52840.go
index 3c7deb031..6af1c11b2 100644
--- a/src/runtime/runtime_nrf52840.go
+++ b/src/runtime/runtime_nrf52840.go
@@ -6,7 +6,7 @@ import (
 	"device/arm"
 	"device/nrf"
 	"machine"
-	"machine/usb/cdc"
+	_ "machine/usb/cdc"
 	"runtime/interrupt"
 	"runtime/volatile"
 )
@@ -26,8 +26,6 @@ func main() {
 }
 
 func init() {
-	cdc.EnableUSBCDC()
-	machine.USBDev.Configure(machine.UARTConfig{})
 	machine.InitSerial()
 	initLFCLK()
 	initRTC()
diff --git a/src/runtime/runtime_rp2.go b/src/runtime/runtime_rp2.go
index 08ae86569..1cd23d6dc 100644
--- a/src/runtime/runtime_rp2.go
+++ b/src/runtime/runtime_rp2.go
@@ -7,7 +7,7 @@ import (
 	"device/rp"
 	"internal/task"
 	"machine"
-	"machine/usb/cdc"
+	_ "machine/usb/cdc"
 	"runtime/interrupt"
 	"runtime/volatile"
 	"unsafe"
@@ -360,8 +360,6 @@ func machineInit()
 func init() {
 	machineInit()
 
-	cdc.EnableUSBCDC()
-	machine.USBDev.Configure(machine.UARTConfig{})
 	machine.InitSerial()
 }