diff --git a/flake.lock b/flake.lock
index d541b769c..877c18b46 100644
--- a/flake.lock
+++ b/flake.lock
@@ -20,16 +20,16 @@
     },
     "nixpkgs": {
       "locked": {
-        "lastModified": 1728500571,
-        "narHash": "sha256-dOymOQ3AfNI4Z337yEwHGohrVQb4yPODCW9MDUyAc4w=",
+        "lastModified": 1747953325,
+        "narHash": "sha256-y2ZtlIlNTuVJUZCqzZAhIw5rrKP4DOSklev6c8PyCkQ=",
         "owner": "NixOS",
         "repo": "nixpkgs",
-        "rev": "d51c28603def282a24fa034bcb007e2bcb5b5dd0",
+        "rev": "55d1f923c480dadce40f5231feb472e81b0bab48",
         "type": "github"
       },
       "original": {
         "id": "nixpkgs",
-        "ref": "nixos-24.05",
+        "ref": "nixos-25.05",
         "type": "indirect"
       }
     },
diff --git a/flake.nix b/flake.nix
index 136e1014f..d7d7feb6c 100644
--- a/flake.nix
+++ b/flake.nix
@@ -34,7 +34,7 @@
   inputs = {
     # Use a recent stable release, but fix the version to make it reproducible.
     # This version should be updated from time to time.
-    nixpkgs.url = "nixpkgs/nixos-24.05";
+    nixpkgs.url = "nixpkgs/nixos-25.05";
     flake-utils.url = "github:numtide/flake-utils";
   };
   outputs = { self, nixpkgs, flake-utils }:
@@ -48,11 +48,11 @@
           buildInputs = [
             # These dependencies are required for building tinygo (go install).
             go
-            llvmPackages_18.llvm
-            llvmPackages_18.libclang
+            llvmPackages_20.llvm
+            llvmPackages_20.libclang
             # Additional dependencies needed at runtime, for building and/or
             # flashing.
-            llvmPackages_18.lld
+            llvmPackages_20.lld
             avrdude
             binaryen
             # Additional dependencies needed for on-chip debugging.
@@ -67,8 +67,11 @@
             # has `md5sum`).
             export MD5SUM=md5sum
 
+            # Work around #4819, missing support for generic type aliases.
+            export GODEBUG=gotypesalias=0
+
             # Ugly hack to make the Clang resources directory available.
-            export GOFLAGS="\"-ldflags=-X github.com/tinygo-org/tinygo/goenv.clangResourceDir=${llvmPackages_18.clang.cc.lib}/lib/clang/18\" -tags=llvm18"
+            export GOFLAGS="\"-ldflags=-X github.com/tinygo-org/tinygo/goenv.clangResourceDir=${llvmPackages_20.clang.cc.lib}/lib/clang/20\" -tags=llvm20"
           '';
         };
       }