diff --git a/ws2812/ws2812_m0_48m.go b/ws2812/ws2812_m0_48m.go
new file mode 100644
index 0000000..7ce7cb3
--- /dev/null
+++ b/ws2812/ws2812_m0_48m.go
@@ -0,0 +1,81 @@
+// +build circuitplay_express itsybitsy_m0
+
+package ws2812
+
+// This file implements the WS2812 protocol for 48MHz Cortex-M0
+// microcontrollers.
+
+import (
+	"device/arm"
+)
+
+// Send a single byte using the WS2812 protocol.
+func (d Device) WriteByte(c byte) error {
+	// For the Cortex-M0 at 48MHz
+	portSet, maskSet := d.Pin.PortMaskSet()
+	portClear, maskClear := d.Pin.PortMaskClear()
+
+	// See:
+	// https://wp.josh.com/2014/05/13/ws2812-neopixels-are-not-so-finicky-once-you-get-to-know-them/
+	// T0H: 10 cycles or 208.3ns
+	// T0L: 39 cycles or 812.5ns -> together 49 cycles or 1020.8ns
+	// T1H: 27 cycles or 562.5ns
+	// T1L: 22 cycles or 458.3ns -> together 49 cycles or 1020.8ns
+	value := uint32(c) << 24
+	arm.AsmFull(`
+	send_bit:
+		str   {maskSet}, {portSet}     @ [2]   T0H and T0L start here
+		lsls  {value}, #1              @ [1]
+		nop                            @ [6]
+		nop
+		nop
+		nop
+		nop
+		nop
+		bcs.n skip_store               @ [1/3]
+		str   {maskClear}, {portClear} @ [2]   T0H -> T0L transition
+	skip_store:
+		nop                            @ [15]
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		str   {maskClear}, {portClear} @ [2]   T1H -> T1L transition
+		nop                            @ [16]
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		nop
+		subs  {i}, #1                  @ [1]
+		bne.n send_bit                 @ [1/3]
+	`, map[string]interface{}{
+		"value":     value,
+		"i":         8,
+		"maskSet":   maskSet,
+		"portSet":   portSet,
+		"maskClear": maskClear,
+		"portClear": portClear,
+	})
+	return nil
+}